Exosomes And The Rise of Birth Tissues
Walter P. Drake, JD, PhD
February 14, 2021
Once I reached the conclusion that amniotic fluid was the “fountain of youth”, I realized that it was the exosomes contained within the amniotic fluid rather than the stem cells that had the potential for major control of diseases and almost futuristic cosmetic results.
Exosomes are a subset of Extracellular Vesicles that are generally lipid encased:
The study of extracellular vesicles (EV’s) has the potential to identify unknown cellular and molecular mechanisms in intercellular communication and in organ homeostatis and disease. Exosomes, with an average diameter of ≈ 100 nanometers, are subsets of EV’s. Their diverse constituents include nucleic acids, proteins, lipids, amino acids, and metabolites, which can reflect their cell of origin.
Actually, this is the progression in thinking from the now famous “paired-mice experiment” showing that Serum Factors and not Stem Cells transferred from a young mouse to an aged mouse caused repair of damaged muscle in the aged mouse. When I first stumbled upon the paired mice experiment almost 10 years ago, and the later experiments showing that only “young” plasma was needed to generate repair of injured mice tissue and other conditions (rather than any transplantation of cells), I found this to be a troubling observation for stem cell therapy. This was troubling because stem cell therapy for the last 20 years worldwide has been concentrating on the collection, identification, expansion (multiplication), and transplantation of stem cells to achieve a therapeutic result.
But as it turns out, and now becoming knowledgeable to a handful of world stem cell experts, it is serum factors and messenger molecules, not stem cells, that will be the true therapeutic breakthrogh in disease control.
Now, the first thing to refresh yourselves about is that the US is last in stem cell therapy. So, for you in the United States, do not be looking in the US for any therapy or stem cell medicine nor any advances in the field. That has been squashed. When we talk about advances in stem cell therapy we are ALWAYS referring to international treatment centers, the great centers in Thailand, Panama, and most recently the excellent new treatment facility in Mexico using exosomes from umbilical cord and amniotic fluids, R3 Stem Cell Institute: https://r3stemcell.com
Curiously though, it was in the US that the need for exosomes rather than stem cells was actually proven. Rather than permit physicians in the US to offer simple in-office stem cell therapies using the patients own stem cells, the US Food and Drug Administration has always been hell-bent on approving “off the shelf” stem cell products. So, it approved bare bones umbilical cord stem cells for use in therapy. Any physician can buy some some UCB cells (stem cells from umbilical cord blood) and inject these into their patients. Problem is, they do not work. Nothing happens. There has never been any therapeutic result observed nor any paper published anywhere in the world demonstrating the effecitiveness of “bare bones” UCB’s for anything!
So, what happend next, beginning around 2019-2020 was the realization (almost 15 years after the paired mice experiment) that it must be exosomes and small messenger molecules, serum factors and the like that are needed. Recall that SVF (stromal vascular fraction) collected from liposuction is the liquid gold of stem cell therapy, cures and controls a variety of conditions and diseases, and is made up of not only stem cells, but a potpourri of exosomes, extracellular vesicles, serum factors, messenger molecules, and endothelial stimulators, all of which participate in achieving various therapeutic results.
So, we can thank the US FDA for proving that stem cells do not work in therapy without associated exosomes and other non-cellular biologics!
And now, as of 2021, the entire field of stem cell therapy is becoming focused on using exosomes. And where are these found? The easiest source is amniotic fluid and other birth tissues like placental tissue, umbilical cord blood, and Wharton’s jelly, all of which have been shown to contain hundreds of identified exosomes. And that is why we are on the trail of Exosome-based cosmetic products!!!